Relationship of histological findings to survival in Hodgkin's disease.

as to histolÃ3gica! type according to the Rye classification, patients with the lymphocytic predominance type of the disease had the best prognosis, those with the nodular sclerosis type had the 2nd best, those with the mixed cellularity type had the 3rd best, and those with the lymphocytic depletion type had the poorest prognosis. In two of the remaining three series, the 5-year survival rate was the same for the mixed cellularity and lymphocytic depletion groups; otherwise, the ranking was identical. In the eighth series, the ranking was the same, except for the fact that patients with the nodular sclerosing type had a slightly better survival rate than those with the lymphocytic predominance type. In all eight studies, there was a clear-cut difference in the survival rates between the nodular sclerosis and mixed cellularity groups. In spite of differences in the types of institutions, and therefore possibly of the patients included and therapy given, and questionable errors in histolÃ3gica! classification in four of the series, there were only four variations from the ranking as to prognosis of the four histolÃ3gica! types in the eight series. A comparison of the series as to the percentage of patients, sex distribution, clinical stage, and survival rates in each histological group suggests that, in some series, the histological type of Hodgkin's